Can believers legitimately pray for divine intervention in physical events like healing, or does such petitionary prayer conflict with scientific and theological principles? The scientific objection to prayer's efficacy rests on a fundamental misunderstanding of science's nature and limitations. While science necessarily operates under the methodological postulate of nature's uniformity, this working assumption cannot be elevated to a metaphysical principle that definitively rules out miraculous intervention. From a theological perspective, an absolute, transcendent God who maintains genuine I-Thou relationships with humanity necessarily implies divine responsiveness to prayer, including physical petitionary requests. Though some raise religio-ethical concerns that such prayers may reflect presumption about altering nature's order for personal benefit, authentic religious dialogue with God cannot exclude discussion of physical suffering and needs. Through methodological analysis, petitionary prayer emerges as valid when accompanied by humble submission to divine will, maintaining essential religious significance for believers while preserving theological integrity through proper acknowledgment of divine sovereignty.